Istvan Mucsi January 11, 2020
Transpl Int. 2020 Jan 09;: BACKGROUND: We assessed the validity of the Edmonton Symptom Assessment System (ESAS-r) in kidney transplant recipients (KTR). METHODS: A cross-sectional sample of 252 KTR was recruited. Individual ESAS-r symptom scores and symptom domain scores were evaluated. Internal consistency, convergent and construct validity were assessed with Cronbach's α, Spearman's rank correlations, and a-priori defined risk group comparisons. RESULTS: Mean(SD) age was 51(16), 58% were male, and 58% Caucasian. ESAS-r Physical, Emotional, and Global Symptom Scores demonstrated good internal consistency (α>0.8 for all). ESAS-r Physical and Global Symptom Scores strongly correlated with PHQ-9 scores (0.72, 95%CI: 0.64-0.78 and 0.74, 95%CI: 0.67-0.80). For a-priori defined risk groups, individual ESAS-r symptom score differed between groups with lower vs. higher eGFR [pain: 1(0-3) vs. 0(0-2), delta=0.18; tiredness: 3(1-5) vs. 1.5(0-4), delta=0.21] and lower vs. higher hemoglobin [tiredness: 3(1-6) vs. 2(0-4), delta=0.27]. ESAS-r Global and Physical Symptom Scores differed between groups with lower vs. higher hemoglobin [13(6-29) vs. 6.5(0-18.5), delta=0.3, and 9(2-19) vs. 4(0-13), delta=0.24] and lower vs. higher eGFR [11(4-20) vs. 6.5(2-13), delta=0.21, and 7(2-16) vs. 3(0-9), delta=0.26]. CONCLUSIONS: These data support reliability and construct validity of ESAS-r in KTR. Future studies should explore its clinical utility for symptom assessment among KTR. PMID: 31919903 [PubMed - as supplied by publisher]

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